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TPMG Colonial Endocrinology

Rheumatology Williamsburg


5424 Discovery Park Boulevard
Building B, Suite 201
Williamsburg, VA 23188

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Telemedicine Now Available – Call to Schedule


(757) 903-4808

Office Hours

Monday: 8:00 a.m. - 4:30 p.m.
Tuesday: 8:00 a.m. - 4:30 p.m.
Wednesday: 8:00 a.m. - 4:30 p.m.
Thursday: 8:00 a.m. - 4:30 p.m.
Friday: 8:00 a.m. - 2:00 p.m.

Office Manager

Donna Thompson


The front desk assistant, Gabrielle, is caring, compassionate, friendly, helpful, and awesome! Thank you!…Read more


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Dr. Karen L. Knudsen is board certified in Endocrinology and Internal Medicine, as well as Endocrine Certification in Neck Ultrasound by the American Association of Clinical Endocrinologists. She has a special interest in adrenal and pituitary disorders, women’s health, and thyroid and diabetes conditions. Dr. Knudsen also performs thyroid ultrasounds and biopsies in the office. In February 2019, John D. Ireland, PA-C joined Dr. Knudsen at the Colonial Endocrinology office, located in the New Town area of Williamsburg. 

At TPMG Colonial Endocrinology we practice traditional, evidence-based endocrinology, which may require the prescription of synthetic hormones. We do not co-manage conditions with naturopaths, chiropractors, or other alternative medicine practitioners. We manage a variety of endocrine conditions, with some of the most common conditions including patients with thyroid issues, including thyroid nodules. Dr. Knudsen performs ultrasounds and biopsies of the thyroid/neck to assess these conditions in office. We manage PCOS and related menstrual issues (we do not do compounded HRT, “hormone therapy” including testosterone in premenopausal women) and patients with diabetes, both type 1 and type 2, as well as Parathyroid disorders related to the endocrine system and Males with hypogonadism.

Patients are seen by appointment. Please contact our office to schedule an appointment.

New and Follow-up Appointments:

Please bring your insurance card(s), photo ID, a complete list of medications, and specialist co-pay (if it applies) to your visit. All co-payments are due at the time of service.


Please contact your primary care physician or diagnosing physician beforehand for a referral, as they are mandatory when making appointments. 

Prescription Refills:

Prescription refill requests must be addressed at the time of your appointment, and any requests outside of this time will be addressed within 24 business hours.


If you have any questions or concerns about your bill, please call our Office Manager.


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